Buy IGF-1 LR3 (Receptor Grade)
Is a premium research reagent for use in cell growth studies, IGF receptors and IGF binding proteins and is more potent than rH IGF-1 and Media Grade IGF-1 LR3 (Receptor Grade) in-vitro due to the drastic increase in biological activity (stronger affinity for the IGF receptor). This increased biological activity is what sets Receptor Grade IGF-1 LR3 (Receptor Grade) apart from Media Grade (standard) IGF-1 LR3 (Receptor Grade). Buy IGF-1 LR3 (Receptor Grade)
Media grade IGF-1 LR3 (Receptor Grade) is more commonly used in commercial cell culture vs mammalian and can also be used as a research reagent at an economical cost to enable studies where biological potency is of less value. To maximize results in an animal-based in-vitro cell study or production, Receptor Grade IGF-1 LR3 (Receptor Grade) should be used exclusively. The supplementation of mammalian cell cultures with Long R3 IGF-1 at a much lower concentration results in more highly elevated productivity than with standard concentrations of insulin and/or standard IGF-1.
IGF-1 LR3 (Receptor Grade) is better able to stimulate the type 1 IGF receptor and thus induce a higher level of intracellular signaling, cell proliferation and inhibition of apoptosis.
IGF-1 LR3 (Receptor Grade) for sale
Receptor Grade IGF-1 LR3 (Receptor Grade) is more biologically active than standard IGF-1 LR3 (Grade Receptor), in-vitro.
Resultantly, Receptor Grade IGF-1 LR3 will deliver superior results in comparison to standard IGF-1 LR3 (Receptor Grade).
IGFB Binding and The Increased Biological Activity of Long R3 IGF-1
By resisting IGFBP-binding, IGF-1 LR3 (Receptor Grade) has a greater effect than IGF-1. The longer duration of action allows for smaller amounts to be used with the same effects. Some IGF-1 derivatives, such as the GPE derivative, made up of just the last three N-terminal amino acids of the IGF-1 protein, have been shown to have therapeutic effects in neurological injuries like stroke. Most studies concerning the effects of IGF-1 derivatives have been carried out in non-human animal models or cell culture studies.
Insulin Like Growth Factor Receptor Interactions
IGF-1 (Grade Receptor) binds to at least two cell surface receptors: IGF-1R and the insulin receptor. The IGF-1 receptor is referred to as the “physiologic” receptor because IGF-1 binds to it with significantly higher affinity (approximately 100 times higher) than it does to the insulin receptor. By binding to IGF-1R, IGF-1 can affect metabolism, cell growth (hypertrophy), differentiation and cell division (hyperplasia), prevention of cell death (apoptosis), normal development, and even malignant growth.
IGF-1R has been implicated in several different types of cancer include breast, prostate, and lung cancer. IGF-1 also binds to the insulin receptor and activates it, thereby encouraging cells to take up glucose from the blood stream.
The effects of IGF-1 on muscle cells are three-fold. Firstly, IGF-1 encourages hyperplasia, or an increase in the number of muscle cells. Secondly, IGF-1 has a strong effect on skeletal muscle – In regards to the life span of satellite cells. Satellite cells support muscle cells, providing them with needed nutrients and helping them to operate efficiently. By increasing the lifespan of these cells, IGF-1 helps to increase their number with muscle tissue.
Finally, IGF-1 encourages differentiation of myoblasts, which is to say that it encourages the conversion of stem cell progeny from nonspecific pluripotent stem cells into dedicated muscle tissue. In this way, IGF-1 increases the rate of muscle development by increasing the rate at which generic stem cells are converted to muscle cells.