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Human chorionic gonadotropin is used as a hormonal therapy to utilize the effects of pituitary derived endogenous gonadotropins, including luteinizing hormone (LH) and Buy HCG Drops Online ,follicle stimulating hormone (FSH).
HCG Drops is a glycoprotein composed of 237 amino acids.1 HCG Drops is similar in structure and function to LH, and is thus prescribed by many physicians to mimic many of the physiological effects of LH. The reason that HCG is prescribed over LH is due to HCG Drops’s more stable nature, greater physiological activity and longer circulating half-life.
HCG Drops has a half-life in the range of hours while LH has a half-life in the range of minutes. The half-life of LH is physiologically important and allows for a pulsatile LH systemic exposure. HCG Drops’s half-life and higher binding affinity for the mutual receptor ultimately allows it to be more biologically active than LH.23
LH and HCG Drops are widely regarded as analogous hormones due to the similarity in the structure of the hormones, including the similar alpha subunits which exhibit similar biologic activities when associated with the beta subunit.4 Furthermore, the HCG Drops alpha subunit is identical to that of LH, FSH and thyroid-stimulating hormone (TSH). The beta subunit is unique to HCG Drops.
LH and HCG share a mutual receptor, however events after receptor binding are different between the two hormones.
Human chorionic gonadotropin (HCG Drops) and a recombinant formulation, called choriogonadotropin alfa (r-HCG Drops), is a gonad-stimulating polypeptide hormone normally secreted by the placenta during pregnancy. The non-recombinant products are obtained from the urine of pregnant women. Recombinant HCG Drops is produced via reco HCG Drops Intratesticular Testosteronembinant DNA techniques in Chinese Hamster Ovary (CHO) cells. The pharmacological actions of HCG Drops and of r-HCG Drops are similar and resemble those of luteinizing hormone (LH); HCG Drops is generally used as a substitute for LH.
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HCG Drops has been used to treat cryptorchidism or hypogonadotropic hypogonadism in males, sometimes in combination with menotropins or follitropin. Interestingly, HCG Drops was introduced for the treatment of cryptorchidism in 1931, and remained the only hormonal agent available to treat the condition until the 1970’s, when gonadotropin-releasing hormone (GnRH) analogs also became a treatment option.
Urine-derived HCG Drops was first approved by the FDA in 1939, and received subsequent approval for additional indications in 1973. Ovidrel®, the first recombinant HCG Drops (r-HCG Drops), received FDA approval for female infertility to induce final follicular maturation on September 20, 2000. Ovidrel® pre-filled syringes received FDA approval in October 2003; manufacturing of Ovidrel® vials has ceased.